Preheat the oven to 400°F and line a baking sheet with parchment paper.
In a large bowl, whisk together the flour, sugar, baking powder, salt, and orange zest.
Cut in the cold butter using a pastry cutter or your fingers until the mixture resembles coarse crumbs.
Stir in the dried cranberries. (If using fresh you will need to cut the in half.)
In a separate bowl, whisk together the cream, egg, and vanilla. Add to the dry ingredients and gently mix just until combined.
Turn the dough out onto a lightly floured surface and shape into an 8-inch circle. Cut into 8 wedges.
Place scones on the prepared baking sheet and bake for 15–18 minutes, or until lightly golden. (I put my oven on 375° and cook for about 10 minutes.)
Let cool slightly before glazing.